Of course, but if you find yourself in one of these instances of editing a large file (search and replacing database dumps is a common use case for me), you'll be disappointed. It's easy to argue that should be left to command line tools, but ST3 actually does a pretty good job at this.

Unless it's a CSV. Or XML. Or JSON, Or <insert another popular format>

I severely doubt that. You don't edit them every day, but:

1) It comes up sometimes, and your editor should cope 2) Having a hard file size limit so low is (to me) indicative of you doing something wrong.