Absolutely. Even if I wasn't using node I'd be using browserify for its modules, its one of the best features of Node and it makes building non-framework apps about as easy. Piecemeal isn't a bad thing if each element is easily replaceable - I tend to prefer specialist libraries which get the feature correct for the project rather than having to do everything the "react/angular/%framework%" way. One size fits all is great when you need to quickly on-board lots of people, but it does reduce your flexibility, and ties you directly to that stack. Things are moving very fast in Web Dev land, and I prefer to not be locked in.

That's not an answer if you are a library author. You can't ship only for browserify users. Which leads to frameworks because to reach everyone (including people who don't use a modular loader at all) you have to have 0 dependencies.