- Impossible to grok as a network admin, as it aggressively tries to work on EVERY network (even when only port 80 is available etc.) - The transition from P2P to centralised means that we enjoy all the downsides of a centralised system (hello NSA) AND all the downsides of P2P (no reliable offline messages, esp. with multiple devices) - The iPhone version is 100% custom UI, looks and acts like a Windows Phone app, and has dropped several features (App Store reviews have not been very favourable) - Closed source, non-sandboxed and from a surveillance-friendly company - A resource hog

That said, Wire looks like a complete non-starter to me.