Flask: you can, but you really shouldn't, at least not for anything you plan to deploy.

http://flask.pocoo.org/docs/python3/#python3-support

http://lucumr.pocoo.org/2014/1/5/unicode-in-2-and-3/

Which kind of sums up the whole Python 3 situation.

Umm, FUD much? It's a real stretch from Ronacher's (entirely reasonable, from what I can see) complaints to "not for anything you plan to deploy."

Are we reading the same articles?

The Python 3 support page is full of "this should work in theory, it's very under-tested, almost nobody is using it, don't blame us if you try it anyway and get rooted."

They did everything to warn you short of installing giant neon signs saying "radioactive, don't use in production."

We've been working with the Oracle connector for MySQL [1] without any problems.

[1] https://dev.mysql.com/downloads/connector/python/

There's also oursql, which isn't API compatible with MySQL-db, but is generally better (and works fine, in my experience).