I follow just a little under 100 people. A lot of those tweets are just some comments about current affairs, tech or random funny tweets. While I use no particular client to filter my tweets, but when I skim through my timeline I usually look for links.

If the tweet doesn't have a link, it is basically 140 characters of someone commenting on something and can be ignored. If it has a link, maybe it could be a tweet pointing to something interesting.