I have tried a lot of different solutions to manage my twitter feed. All from Desktop apps (Tweetdeck, Metrotwit) to commandline apps (TTytter + more). In the end i settled for Tweetbot[1] for iOS (Mainly iPad) so i have limited myself to only check Twitter when i'm on my iPad, which fits me quite nicely, so i dont get distracted when working on my PC.

[1] http://tapbots.com/software/tweetbot/