> System uptime is a consideration whenever I need my computer for something immediately, but my choice of Debian is not only about that.

Maybe you should try Arch on one of your machines. I have a lot of experience with both Debian and Arch, having used both extensively on all kinds of hardware over long periods of time, and have found Arch to be ideal on desktop. Having access to the latest software and drivers is a huge plus with recent hardware. I have never encountered breaking changes.