Personal experience: the first time i took buproprion/naltrexone it became clear to me why people that arent and have never been overweight think "just eat less move more" is the only advice you need.
Except it's not typically very effectively actionable advice.
It's more in the realm of "just be happy" to a depressed person. Sure, that'd help a lot. It's the how that's tough. So we move the levers that aren't rusted solid first.
