I do know from previous discussions that some companies are in us-east-1 because of business partnerships with other inhabitants and if one moves out the costs and latency goes up. So they are all stuck in this boat together.
Still, it would make a bit of sense if you can find a place in your code where crossing a region hurts less, to move some of your services to a different region.
While your business partners will understand that you’re down while they’re down, will your customers? You called yesterday to say their order was ready, and now they can’t pick it up?