I suspect anyone lacking a base level of self awareness and self mastery could be considered “incompatible” with anyone else, especially another lacking said mastery.
I could study myself and my spouse, gain insight through therapy and the study of psychology and evolutionary biology into the nuance at the source of my interpersonal problems — or, I could outsource the insight to an LLM to exploit another’s weaknesses, leaving my own unattended to.
While I don’t rule out the existence of truly incompatible parties, I wonder how many otherwise salvageable relationships will be undermined by this practice.