In Guix, packages are typically dynamically linked against libraries in the store. Static linking changes not just the configure flags, but also how dependencies are pulled in - you'd have to make sure every dependency is available as a static .a library for the target platform and many Guix packages aren't built with static artifacts at all.

So I can understand needing to modify the build flags for all dependencies to generate static artefacts for the final binary, and regenerating these from scratch... but still, isn't that just a single extra parameter in their compile args?

Fear.