> The AlphaFold3 analysis (the AI contribution) literally accounts for a few panels in a supplementary figure - it didn't even help guide their choice of small molecule inhibitors since those were already known.

(Disclaimer: I'm the author of a competing approach)

Searching for new small-molecule inhibitors requires going through millions of novel compounds. But AlphaFold3 was evaluated on a dataset that tends to be repetitive: https://olegtrott.substack.com/p/are-alphafolds-new-results-...