Neither Java nor JS encourages the use of native extensions to the same degree that Python does. So some of it is a fundamental difference in approach: Python has gotten very far by offloading hot paths into native code instead of optimizing the interpreter itself.
(Recent positive developments in Python’s interpreted performance have subverted this informal tendency.)
Node also introduced a stable extension API that people could build native code against relatively early in its history compared to Python. That and the general velocity of the V8 interpreter and its complex API kept developers from reaching in like they did with Python, or leaving tons of libraries in the ecosystem that are too critical to drop.
Yeah, I think it's mostly about complexity: CPython's APIs also change quite a bit, but they're pretty simple (in the "simple enough to hang yourself with" sense).
> Neither Java nor JS encourages the use of native extensions to the same degree that Python does.
You already had billions of lines of Java and JS code that HAD to be sped up. So they had no alternative. If python had gone down the same route, speeding it up without caveats would have been that much easier.
I don't think that's the reason. All three ecosystems had the same inflection point, and chose different solutions to it. Python's was especially "easy" since the C API was already widely used and there were no other particular constraints (WORA for Java, pervasive async for JS) that impeded it.
(Recent positive developments in Python’s interpreted performance have subverted this informal tendency.)