Don't know about the biggest, although it was quite big, , but the best shell program I ever wrote was in ReXX for a couple of IBM 4381s running VM/CMS which did distributed printing across a number of physical sites. It saved us a ton of money as it only needed a cheap serial terminal and printer and saved us so much money when IBM was wanting to charge us an ungodly amount for their own printers and associated comms. One of pieces of software I'm most proud of (written in the mid 1980s), to this day.
Like much of what i wrote before the days of distributed version control, this is now lost in the mists of time. And the code wouldn't belong to me anyway.
I remember an article I read, probably around 1997 about cgi languages. It considered I believe, Rexx, TCL, Perl and Python. I bet it's at archive.org somewhere
I tried metacard after reading that. It ran on linux: http://www.sai.msu.su/sal/F/5/metacard.gif ... I think I might have written some things with it. Cool, good luck on me trying to find 26 year old software.
You can totally still run this if you want btw - just download some old linux ISOs from archive.org and install it in a VM ... hope they survive all their lawsuits; we're so lucky to have them around.