It is an incredible but true fact there’s often no known way to repair large organizations once they have gotten sufficiently sick. They have to be dissolved and new companies have to be built from the ground up. As you suggest, this is incredibly destructive. The employees and expertise aren’t destroyed — they start and join the new companies — but the relationships and institutional knowledge is largely lost. But it is recoverable, and the alternative is often worse.
> All happy families are alike; each unhappy family is unhappy in its own way.
There is no scripted formula to repair a large organization. Each one needs to be addressed in a way that is particular to that organization, its culture, and its ultimate desired end state.
One could look at the Gil Amelio to Steve Jobs Apple - that was a turn around of a not small organization. However, what worked for Apple certainly won't work for Boeing.