Fractyl Healthcare is working on a gene therapy targeting this pathway. Chronic maintenance is a temporary hack imho. Long term fix is patching the genetic bug around a miswired reward center.

https://news.ycombinator.com/item?id=38495653

there's also ultrasonic brain surgery to fix the miswired reward center.

https://youtu.be/7BGtVJ3lBdE?t=869

So a drug to counteract the effects of the drug to counteract the effects of a poisonous calory-provisioning industry. Perfect!

Sort of? Gene therapy is a permanent fix where as GLP-1 agonist compounds are needed perpetually for maintenance.

https://getyarn.io/yarn-clip/dd4f2296-2186-45d6-b42a-10966b4...