The mortality for interplanetary spaceflight, in the near future, will likely be an order of magnitude lower than it was of the Age of Exploration’s front line. The comparison is terrible for several reasons. But it’s one that speaks to spirit, not means. If the Americas were uninhabited, they would have been—to colonial-era Europe—of comparable difficulty to setting up a permanent Lunar or Martian. (Note: NOT permanent population. Reproduction is harder.)
> Americas have trees, meat, rivers, oxygen, grasslands, forests, birds
Exploitable constrained human power shipped across a sea by way of a costly, lossy transport system. Colonising the Americas without a latent labour pool and social hierarchy to swap over would have been near impossible for pre-industrial Europe.
It would have required long-term support across months of shipping and communication time for purchase of unknown resources in unknown time scales in respect of unknown risks. Sound familiar?