Do you think LSD is comparable to a lobotomy?

And critically, lobotomy isn't a change from one set of mental states to another. That big chunk of brain doesn't grow back.

Memories once missing don’t grow back either. The most extreme cases of LSD use have impacted such basic functions as limiting people’s ability to communicate.

Post lobotomy people generally weren’t brain dead, even if diminished. So for extreme cases, yes it’s a solid comparison.