Coronavirus were thought to be non-vaccinable, even worse than the flu. They are behind a lot of winter colds, and they are a great pain in veterinary. Veterinaries are the ones that were pessimistic before mRna vaccines, because they were trying vaccines for decades to no avail.
Measless and chickenpox are very stable, and even the body gains inmunity for life just being exposed to it in the childhood.
All of them are virus the same way an ant and a elephant are animals. You might kill the ant with a magnifying glass, but good luck trying with th elephant.
> Coronavirus were thought to be non-vaccinable, even worse than the flu.
Citation needed. I think the biggest reason there’s no common cold vaccine is that there are too many common cold varieties, often not even related to each other.
Dengue was thought to be a difficult target, and are some non-mRNA vaccines looking pretty good in trials right now.
I refered to veterinary as a source of pesimism. There are a number of veterinary serious problems related to coronavirus. I'm going to just refer to https://en.wikipedia.org/wiki/Coronavirus#Infection_in_anima.... Labs are trying to get vaccinations for those infections for years if not decades, to no avail. We are talking of millions, if not billions, in farm loses, so not a minor issue.
When all the SARS-CoV-2 event was raging, people from veterinary were very pesimistic, because they knew coronaviruses change so rapidly that no (traditional) vaccine holds for long enough. Luckily, mRNA vaccines shorten the window between variant detection and roll-out. They are trying genetically altered viruses that include multiple versions of the S protein, to induce the immunity, so it's not like they are working with ancient technology or no resources.
You also recognize that "dengue was thought to be a difficult target", and indeed it was. You don't need [citation] to assert that. The fact that we were trying to vaccinate against Dengue for almost a century is [citation] enough. The same holds true for coronavirus, specially in veterinary.
Measless and chickenpox are very stable, and even the body gains inmunity for life just being exposed to it in the childhood.
All of them are virus the same way an ant and a elephant are animals. You might kill the ant with a magnifying glass, but good luck trying with th elephant.