I've been programming (and gaming) 40+ years now, and weirdly, the main RSI injury I have is actually from when I was a kid using the Atari joystick as a left hander (this one https://upload.wikimedia.org/wikipedia/commons/3/33/Atari-26... )

now any fine motion where I need any kind of pinching motion for more than 30 seconds is super painful and by thumb pretty much gives up (using my thumb to tap the spacebar on the keyboard is fine though).

Since learning about RSI about 30+ years ago, I regularly exercise and stretch my hands, so I think that has helped a lot.