When building larger projects you should consider using a MVP (model-view-controller) pattern to separate your view code from the business logic. This way you can keep the view code simple, and the model code out from view-specific abstractions. This is called separation of concerns and is the primary way to build scaleable applications. I'll tackle this topic in detail along with a more complex demo application when Nue MVC project is released: https://nuejs.org/tools/#nue-mvc
Nue will be absolutely fantastic for scaling large applications and teams!
I'm starting to become a fan of your motivation (although count = 0 is still not ES6 classes variables). Good luck scaling it! Are you creating this framework out of your own necessity or just because it can be done? Any medium/large app using it to showcase?
Nue will be absolutely fantastic for scaling large applications and teams!