Yep, there's a reason I have Blackmagic quad 4K capture cards in my workstation. Syncing multiple video streams with USB capture cards would be nigh impossible even if you put them on separate USB controllers. Ingest over USB is fine (though slow) but pretty much every USB capture card does its own internal compression, as you point out, and then involves the CPU to decompress it and get it into VRAM or DRAM.