In terms of actual compute speed, Python is still significantly slower, and although 3.11's changes will help quite a bit, V8 is also just insane.
In terms of I/O speed, uvloop (https://magic.io/blog/uvloop-blazing-fast-python-networking/) can beat Node quite handily, so if you're more concerned with being able to handle requests than doing anything major during those requests, Python might be comparable.
In terms of actual compute speed, Python is still significantly slower, and although 3.11's changes will help quite a bit, V8 is also just insane.
In terms of I/O speed, uvloop (https://magic.io/blog/uvloop-blazing-fast-python-networking/) can beat Node quite handily, so if you're more concerned with being able to handle requests than doing anything major during those requests, Python might be comparable.