Totally happens even with insects. The biotech industry started using BT genes (a fungus which takes care of corn ear worm) in GMO corn. Previously, BT was an organically approved pesticide, carefully applied by growers according to guidelines which made sure the target pest did not develop resistance. But with the genes making the nasties continually = BT all the time = excellent evolutionary driver = cases of resistant corn ear worm appearing. Biotech reaction: "we will just think of something new and keep doing it!" ref: https://entomologytoday.org/2018/10/23/problems-driving-resi...