Certainly! I have 4 keys for mouse movement (left, right, up, down) in my "mouse" layer. If you tap them it moves the mouse a little bit in that direction, if you hold the keys then the mouse moves slow at first, then starts to speed up (that is more controlled at the OS level though). You can also add keys to change the acceleration.
I have these 4 direction keys on my middle and index fingers of each hand. There are also keys for clicking which I have on my ring fingers, and on my palm for when I need to click down and drag.
It takes getting used to obviously but I don't mind it now. It works for 95% of my uses but I'll admit if I need really fine control, I'll use my trackpad for a couple of seconds.
