No, my response is that your screen reader sucks. For example a bad screen reader might require that an image of an apple has to be labelled apple for it to work, but a good one could just see that image and recognize that it is a picture of an apple.
Ok, and what does that change? Are you gonna invent that software for those people? If it already exists, are you gonna give them a license? All because you didn't feel like spending half an hour thinking about accessibility.
It's not my job to work on your screen reader. Complaints about its effectiveness should go towards the developers of the screen reader software. If everyone's screen leader software sucks then there is likely a business opportunity for someone to make a better one. Also you are trivializing it by saying half an hour. Even if that was true it would be half an hour for every single website in existence. That doesn't scale. What scales is making a better screen reader.
Response: "It's not my fault you're blind. Ticket closed."