Tmux is awesome. Although I never understood why they used ctrl-b instead of ctrl-a as the default though - incompatible with screen and hard to reach with one hand.
The home key is in a terrible, terrible place on the keyboard and missing in many laptop keyboards. Ctrl-A is much easier to reach while touch typing, especially after remapping Caps Lock to Ctrl.
And my own personal muscle memory prefers a different setup, so that's why these things should be configurable, but the defaults should probably match common conventions don't you think?
I disliked ctrl-a and ctrl-b as prefixes because both conflict with using emacs keybindings. However, it was convenient that, by default, they were different. When I first used tmux I was still using screen on some servers (that I didn't fully control). Being able to use screen on the server through my tmux session without having to double type the prefix was useful.
CTRL-A is the default for GNU Screen, and when you're developing a terminal multiplexor, you sometimes want to work on it inside the terminal multiplexor you're hoping to improve upon. :)