Queued it up for this weekend. I'm sure I could listen to Ms. Wilson talk about CPUs for hours. To have been designing chips in those early days and still making them today must be as mind-blowing to her as the advances in software have been for us programmers.
This is an enlightening talk about the current state of the industry.
Tldr: We're looking at 28nm process forever leading to boards containing specialized SoCs. Heat and sequential logic remain the most difficult challenges.