They are lifelong drugs though - you go off it and the weight and “food noise” come back. If you grow to used to them you have to switch from ozempic to moniourno to whatever diff thing then circle around again.
Not saying the effort is the same just that its def not a decision to take lightly and just start doing thinking its a few shots and bam your down 50 lbs forever - still have to do the mental reprogramming to not eat the bad stuff and exercise regularly
I can hear russia/iran now “darn they thwarted our plans to take out el paso and that mountain. There are absolutely zero other targets in the vicinity we can fly to. Zero in a 100 mile radius our drone has a capability to get to within 10 days. I mean if we had 11 days sure but how do they know 10 days???”
My psychiatrist is really interested in how it affects anxiety and depression as he has now seena number of improvements from a bunch of patients (including myself) who use the drug. Im on meds for both and only after i started on monjourno did i feel a signifigant change. The food cravings gone due to the nuerological effects but the stress levels lower as it seems to be impacting seratonin levels in ways as you increase dose.
The most surprising effect of Mounjaro, at least initially was that it drastically reduced by desire to drink beer, and when I started, my drinking was at a very unhealthy level (beer calories being a major factor in my weight problem). But maybe I'm an odd case, as I had a real beer habit but don't like wine and very rarely touched spirits.
Actually losing some weight as well as cutting my drinking down, helped me with depression far more than SSRIs (which had previously led to even faster weight gain)
Unfortunately, the effects started to diminish somewhat after about a year on it, as if I was building up a bit of a tolerance to the drug. And then I switched to Wegovy (=Ozempic) after big UK price hikes to Mounjaro, and found it much less effective, started gaining weight again (winter/xmas didn't help). Switching back to Mounjaro at the moment, but having to slowly step back up from a lower dose. Not expecting to see the initial near-miraculous effects again, expecting to have to combine it with some actual willpower and more exercise going forwards.
The really beautiful thing now is that, with the evidence from GLP-1 drugs as a class, we're seeing 3 things: new targets for all kinds of things, that were previously discarded as "too difficult to make into medication", and in addition, injectable treatments - for a long, long time anything that required injections was just ruled out at the mechanism level. The third thing is that pharmaceutical industry has learned how to hit multiple targets with a single drug - previously most drugs were formulated to hit at most one or two receptors, and now we're seeing work on quad or 5-way drugs.
I'm super optimistic, the pipeline for future medications in these classes and other related ones are enormous. Huge effects both for me personally but for the world as a whole, a world in which obesity and other chronic behavioral conditions are treated more like cancer than smoking - even smoking itself!
I've had a similar experience where I'd be craving a beer, but not really craving alcohol since wine or spirits didn't sound appealing at all. I think it might actually be the hops and not the alcohol.
I don't know if it's common in the UK, but in the US, a lot of breweries have started making hop water. I've found that it can really scratch that itch. Even just a hop tea might work if you can't find pre-made hop water.
It sounds weird, but it's actually delicious with nice floral and citrus notes and just enough bitterness that you don't drink it too quickly.
It’s not just you. I’ve known several people who lost their desire to drink beer specifically on these drugs. I didn’t personally experience it, but then I am more of a whiskey guy.
Mounjaro is widely known to cause bad hangovers and side effects while drinking isn't it? That's what I gleaned from my research. I'm a little surprised you didn't come across that
Curious also if you're considering staying on the lowest dose for cost purposes? I've ignored all advice to step up from 2.5mg and I can even go 10-14 days without noticing too much, but weight loss is slow compared to others (12kg in 6 months). But that's how I want it to be honest.
Though I guess lower dose for longer might work out more expensive
> a number of improvements from a bunch of patients (including myself) who use the drug.
Does that include people who haven't lost weight on the drug? I imagine a lot of people will start to feel better when they look better and are healthier.
Semaglutide has a warning about not being suitable for folks with depression. I don't think I've seen any changes to my moods. I'm type-II bipolar and if anything my depression episodes are slightly worse now.
The most noticeable jump has been at 10mg but i started noticing it from the beginning of 2.5 to 5 to 7.5 over a 6 month period but something about 10 just hit different but only on my 2nd month of it now. Less anxiety about things i was hit by before and mood improved overall
Some forms of magnesium trigger more stool my movement than others. And there are many forms.
I had opposite problem with it, tried ti find what won't cause it since I have a problem with it too behind with. Also sour kraut triggers me almost always and instant toilet break.
You mentioned elsewhere that milk of magnesia worked, so is it possible that you received a bunk product? I know this is a common issue with supplements and there are some neutral third-party test labs for this.
Was my glucose under control without glp-1's? Yeah I could manage an a1c of 5.4-5.6 with metformin but I was still hovering near 300 lbs.
With glp-1's I'm down over 50 lbs, my a1c is a much more manageable around 4.0-4.5 and it makes it much easier to exercise and portion control is a huge benefit. Not to mention a buncha other things like triglicerides and blood pressure have come down due to exercise and eating better. it sucks i have to take it forever, but at the same time i feel a ton better physically, and if i loose 50 more lbs, and labs continue to show improvement, i can reduce the cocktail of other meds I'm on my doc says.
Cigna denied me at first until my doc appealed twice. Cigna wouldnt cover because i wasnt a full diabetic so wasnt on insulin. I would've had to pay close to $1k a month to take it otherwise. Thank goodness for a tenacious doctor!
> I would've had to pay close to $1k a month to take it otherwise.
If your frame of reference for GLP-1 prices is in like, 2024 or earlier, check prices again. They've come down a lot. You can get tirzepatide from Lilly without insurance coverage for under $500/mo (a little less for the smaller doses): https://investor.lilly.com/news-releases/news-release-detail...
I've been taking metformin off-label for weight loss, and it's been working well. I'm a little annoyed that I have to resort to off label stuff because I too have Cigna and I have not been successful at getting them to cover it.
I think it's more my employer's fault than anything else; fortunately metformin actually seems to be doing the job. They won't cover that either but even without insurance it's so cheap that it's not worth complaining about.
The constant back and forth between architecture and product and project management roles is the new norm for more senior/staff engineers it feels like. rarly do i get an opportunity to work on code during regular hours.
my days are spent in meetings discussion how to implement things or why do it certain ways - when most of that time spend asking inevitably turns into "when can this be ready?"....well if you didnt have me stuck discussing it for the last 6 months it would've been ready yesterday like you wanted.
I used the CIA factbook so much in college in the early 2000's when looking at so many things. When researching countries to support and travel to it made sense to vreview it beforehand. Its insane that this as a resource would be taken down.
It gets cited a lot in immigration litigation as well (eg in asylum arguments) because it's an unimpeachable factual source that the government's lawyers can't reasonably dispute.
And that's not necessarily anti-intellectual or in opposition to truth. When "seeing like a state", a government doesn't have a view of most actual facts, like "was this person actually in danger" or "is this person repeating the exact same story as the ten people before them". It only knows facts legitimated by its own systems. When those facts force it to take actions that are harmful and dumb, the government is wise to stop defining those as facts.
For example, if the army keeps launching raids that kill civilians because the government can only track progress through body counts, it is not "facts are the enemy" to stop counting the bodies. (Obviously it would be wiser to stop using the counts as the deciding factor, but if the generals have different values than the government, as immigration courts do, then stopping the count is the only way to stop the bleeding.)
If you were applying for asylum because the conditions in your country were so oppressive to you as a political actor or member of a disfavored ethnic group, you could support your application with relevant data from the CIA world factbook describing general conditions in that country. As a publication of the US government, those factual claims would not be lightly dismissable or disputable the way third party opinions might.
this is something that also never made sense to me - it felt like star wars got it right - for repairs and remedial tasks a trash can (rs-d2) or all the little service droids are more appropriate, but c3p0 or other nurse and protocol droids makes sense to look more humanistic since they serve functions to facilitate human activitiy - but there is no way those functions are numerous enough to be priofitable.
Not saying the effort is the same just that its def not a decision to take lightly and just start doing thinking its a few shots and bam your down 50 lbs forever - still have to do the mental reprogramming to not eat the bad stuff and exercise regularly