While I can't speak to whether there are enzymes for the proper copy/paste I do have a set of random cancer related bits I've picked up over the years.
There are some basic, well-known nutritional interventions that are generally important/critical for DNA repair processes. The 2 main ones are Vitamin D and Magnesium. Ensuring adequate amount of these tend to be helpful (most folks aren't getting enough sun and greens).
Other than that, a steady and adequate source of the substrates seems to be important: ie protein (nitrogen), and phosphates.
One of the interesting bits about some cancer cells is that while they simply haven't gone through apoptosis, physical sheer stress incurred from physical activity (exercise) can cause cancer cells that travel beyond the tumor point (before it becomes metastatic) to finally self destruct.
It seems important to me that the best strategy for cancer is the compounding of many different strategies that optimize the body's innate defenses to run optimally.
It does seem that ketogenic diets may have adjuvant properties, but there is yet to be a clinical trial that demonstrates it, so it's basically stuck in paper and R&D stages as to whether being in a ketogenic state can be one of the last areas that may help cancer patients extend lifetime from say 1 year to 2 years.
I generally agree. It's all interconnected, and we could point to a singular cause, but to treat them all as one and of the same class of disease seems reductive and not useful.
Though, to be play devil's advocate for a second, it does seem that diabetes is typically where the symptoms start, and we do understand that diabetes is fundamentally metabolic and/or functional dysfunction in 1 or more of 7-ish different areas.
I think it's the level of perspective zoom + timing we take that makes the article's assertion either useful or not.
If we zoom out, while catching disease early on, and we address the metabolic conditions via lifestyle and/or certain drugs like GLP1, then we prevent the need to intervene on the kidney and cardiac front.
But if we zoom in to a specific issue, after disease has progressed a profound amount, a GLP1 intervention may be too little, too late.
Hopefully though, this may help the messaging to folks that if they are contending with metabolic disease that presents as diabetes, introducing lifestyle and pharma interventions early may be helpful on the larger epidemiological front.
An interesting FYI is a comment made by Peter Attia on his podcast.
He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss.
They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects.
It seems like GLP1, even in skinny patients (implied by Attia in this particular case), has metabolic benefits.
The longevity community seems to be hinting that there may be geroprotective aspects of GLp1 as well, so we may be looking at the benefits beyond weight loss for metabolism.
It shouldn't make any difference where you pin it, it's systemic it just has to be administered subcutaneously because it's a peptide and it isn't orally active.
Don't listen to these YouTubers about health and fitness, most of them are clueless
It shouldn't, and yet for me it seems to make a difference! I don't think it's placebo, because I am really losing weight. My anecdata: When I start with a particular dose of GLP-1, I inject in thigh. I get strong appetite suppression, heart rate increase, digestion slow down etc. After some time, the effect decreases as my body adjusts. I then move injection to abdomen, and I get a huge bump in suppression, systemic effects, etc. No idea why this happens, but I've seen it with Zepbound and 5, 7.5, and 10mg. It's allowed me to stay on each dose for far longer than my doctor expected.
Usually this type of anecdata becomes the basis of legitimate, controlled studies and over time can inform and/or adjust.
It would be premature to simply write off all influencers or limiting to only accept the medical profession as the immutable truth.
The reality tends to exist somewhere in the middle, outside of a formal proof.
I've listened to many health influencers and among the legitimate and balanced tend to be Rhonda Patrick and Peter Attia.
Attia provides guidelines for how to think about items, but usually it's the fan base that tends to sully the messaging as the base tends to be far more polarized and dogmatic over bits.
It is interesting to see that there is another poster confirming a slightly different effect though. Regardless of things being "systemic", just understanding that fluids dynamics are complex, I imagine diffusion of a systemic molecule like GLp1 could possibly be variable? Or perhaps there is a localized tissue fatigue?
Many potential options do exist to propose as hypothesis.
Peter Attia is a graduate of Stanford medical school and spent 5 years in surgical residency at Johns Hopkins, and his podcast is largely using his expertise to give context to recently published research. His opinions are always pretty directly linked to peer reviewed research and he updates his stances as new research becomes available and explains why (eg, his shift away from fasting).
He really shouldn't be lumped in with the general "health and fitness Youtubers".
While the area under the curve for glp1 administration may be the same, good chance that the story is informing us of a mechanism such as the absorption rate between two different sites.
Slower absorption in the thigh may blunt the immediate peak dosing and the acute hunger effects.
As always, the small details matter. I'd guess that pharmacology also has their own thundering herd problem with the dosing of certain drugs.
One of the interesting bits about pharmacology seems to not be the active molecule as much as the innovations in delivery mechanism.
I've noticed similar satiation with psyllium as well.
I do a 32hr fast once a week and will consume a scoop of psyllium when I get hungry and it's quite filling for 2-3 hours before the hunger kicks back in.
As an East Asian, not really trying to argue that China hasn’t accomplished great things.
While I can’t speak directly to this, but from watching The China Show on YouTube, the tradeoff to the amazing amenities is that the personal-injury risk from failing infrastructure has been fatal, but covered up by their propaganda. Anyone on the receiving end of it, will deal with devastating consequences, if not fatal.
Infrastructure and manufacturing corners are cut in ways that look great, but literally kill their population and tourists.
Building foundations are not thick enough, buildings aren’t built to proper fire safety standards, underground pipes leak, leading to roads constantly failing, high rises burn down, sewage pipes literally blow up due to methane build up like someone detonated a bomb.
Drainage grates are fake and flooding cities, drowning people in vehicles, while the QA of car battery manufacturing is causing electric fleets of cars in parking lots to burn.
And the aforementioned occurrences are happening in tier1 cities.
I sound hyperbolic, but China is great at quickly cleaning up and quickly rebuilding, so it doesn’t seem nearly as bad as it does.
Once I learned about the infrastructure, I realized my cousin’s business trip accident in China was not a randomly rare accident.
He broke his back in China when his rental car’s front wheel popped off the car.
Chances are most folks are fine if they go. But I would be very weary, because the probability of a disaster is not nearly as high as it ought to be.
> the QA of car battery manufacturing is causing electric fleets of cars in parking lots to burn
I've seen a lot of grumbling on this site about why the U.S. doesn't have access to cheap EVs like China, but it's almost entirely because the cheap EVs that China is pumping out aren't even close to being up to the U.S.'s stringent safety standards.
Eventually they will be safe enough, and they will also be more expensive.
I saw an interview with the director of the FBI describing FBI headquarters as having nets on all sides, so falling debris don’t kill people on the ground.
The fact that the FBI, which is institutionally highly defended, feels the need to spend money and effort on stopping falling debris, tells you something about how accountable government agencies are.
It's not like cooking at home isn't going to yield quite some resistance. A salad is equally as easy to go buy.
I think at the office my escapist tendencies just kick in: anything for a reprieve of the more stressful environment I was in.
When I work with nice colleagues and stress levels are okay, we would usually go out for lunch and I'd eat much better. I think it's a combination of stress and commuting downtown that made go for worse options. Dunno…
This rhetoric of “terrorists” is getting quite tiresome.
The world has been watching for over 2 years the atrocities occurring in Gaza and Israel and its people have has lost its credibility to its victimhood on the world stage.
This article is simply 1 extra reporting on a million of Israel’s offenses in the name of terrorism.
My recent thoughts on why the US is complicit is that Israel is America's "bad cop" of the world. The trade is that the US will allow Israel to act with impunity in the region as long as Israel gets to be the bad guys to the world.
The reasoning for this is action about nuclear weapons programs. Israel gets to have nukes, developed by sending US expertise to Israel, while Israel has not been subject to nuclear investigation programs.
If things ever got bad, the US doesn't want to nuke the world, then face retribution, they want Israel to shoulder that burden.
There are some basic, well-known nutritional interventions that are generally important/critical for DNA repair processes. The 2 main ones are Vitamin D and Magnesium. Ensuring adequate amount of these tend to be helpful (most folks aren't getting enough sun and greens).
Other than that, a steady and adequate source of the substrates seems to be important: ie protein (nitrogen), and phosphates.
One of the interesting bits about some cancer cells is that while they simply haven't gone through apoptosis, physical sheer stress incurred from physical activity (exercise) can cause cancer cells that travel beyond the tumor point (before it becomes metastatic) to finally self destruct.
It seems important to me that the best strategy for cancer is the compounding of many different strategies that optimize the body's innate defenses to run optimally.
It does seem that ketogenic diets may have adjuvant properties, but there is yet to be a clinical trial that demonstrates it, so it's basically stuck in paper and R&D stages as to whether being in a ketogenic state can be one of the last areas that may help cancer patients extend lifetime from say 1 year to 2 years.
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