Isolation doesn't matter if you're absorbed in your work since your work is your world. If work stagnates (a project, a startup or a job) that's when it's felt.
The trick is to always love what you do and to feel part of something whether it's guaranteed to succeed or not.
This remains to be seen. I just signed the lease on Monday for the space and we are doing cleaning and some minimal construction right now.
I live in Helena, Montana. We have a very small startup/tech community here, but we do have a lot of people who telecommute or freelance for out-of-state clients. Ideally, we'll get a mixture of these people. I think the diversity is what's really important.
Outside of Helena, in Bozeman and Missoula, there is a much larger startup community that's really starting to take off. I try to drive down for meetups a few times a month and participate in as many things as possible.
So far, the initial response has been overwhelmingly positive. Rent is really cheap (my father-in-law owns the building, that helps) and I'm not trying to make a living off of the coworking space itself. It won't take many members to get the space self-sustaining and I'm confident that we can get there quickly even with the small population.
The trick is to always love what you do and to feel part of something whether it's guaranteed to succeed or not.
I'm finding this out slowly.