That's great and all, but when you've got multiple goals in multiple domains, something is going to fall to the bottom, or, more likely, right off it. There is only triage and its attendant guilt.
I'm completely unfamiliar with this stuff, but from the article:
"In risk individuals, a thymine (T) is replaced by a cytosine (C) nucleobase, which disrupts repression of the control region and turns on IRX3 and IRX5. This then turns off thermogenesis, leading to lipid accumulation and ultimately obesity... Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes."
So yes, CC is taken to mean "risk" and CT is likewise "non-risk".
As always, one finding doesn't indicate ultimate truth, so take this all with a grain of salt (or not, depending on what 23andMe has to say about your sodium intake).
"Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes."
Good catch. I just saw another article her eabout "PR for startups," more useful than anyone realizes.
>One of the most surprising things I discovered during my brief business career was the existence of the PR industry, lurking like a huge, quiet submarine beneath the news. Of the stories you read in traditional media that aren't about politics, crimes, or disasters, more than half probably come from PR firms.
I've felt more or less the same as you and recently I've found Test-Driven Development with Python[0] to be a really nice resource. It is first and foremost a TDD book, which I certainly appreciate, but it takes you through creating an app in a (to my eyes at least) fairly rigorous way. It probably shouldn't serve as an introduction to Django but for someone who has a basic idea of how a project is put together but has never connected those dots, it might be really helpful.
Wallace Stevens is a favorite of mine. His work has been described as "rigorous", which I would agree with. He is an inspiration to me due to his ability to straddle two worlds: his day job was mainly as an insurance executive, but he flowered late and won a Pulitzer for his poetry. I particularly like "The Emperor of Ice Cream":
Call the roller of big cigars,
The muscular one, and bid him whip
In kitchen cups concupiscent curds.
Let the wenches dawdle in such dress
As they are used to wear, and let the boys
Bring flowers in last month's newspapers.
Let be be finale of seem.
The only emperor is the emperor of ice-cream.
Take from the dresser of deal,
Lacking the three glass knobs, that sheet
On which she embroidered fantails once
And spread it so as to cover her face.
If her horny feet protrude, they come
To show how cold she is, and dumb.
Let the lamp affix its beam.
The only emperor is the emperor of ice-cream.
One must have a mind of winter
To regard the frost and the boughs
Of the pine-trees crusted with snow;
And have been cold a long time
To behold the junipers shagged with ice,
The spruces rough in the distant glitter
Of the January sun; and not to think
Of any misery in the sound of the wind,
In the sound of a few leaves,
Which is the sound of the land
Full of the same wind
That is blowing in the same bare place
For the listener, who listens in the snow,
And, nothing himself, beholds
Nothing that is not there and the nothing that is.
The palm at the end of the mind,
Beyond the last thought, rises
In the bronze distance.
A gold-feathered bird
Sings in the palm, without human meaning,
Without human feeling, a foreign song.
You know then that it is not the reason
That makes us happy or unhappy.
The bird sings. Its feathers shine.
The palm stands on the edge of space.
The wind moves slowly in the branches.
The bird’s fire-fangled feathers dangle down.
It's not clear from the article that that's a smoking gun. Just prior to that point, we see:
"Elevated levels of radon and carbon monoxide were detected but later ruled out as a cause.", with a link to a Russian page that, Google Translated, seems to actually indicate that CO is still a leading suspect. However, the article immediately goes on to apparently quote from the same Russian page that
"...some of houses (sic) of the affected residents had carbon monoxide levels that were ten times higher than recommended. This... could have caused similar symptoms to the “sleeping sickness”."
So the article itself seems a little sloppy. Beyond that, I wonder what the sickness relationship is between high-CO houses and all inhabitants of them, given that at least one inhabitant per house has experienced the sickness. Is there a correlation? Also, is the social structure of the village such that there are frequent visitations to most or every home? If so, then one might expect to experience the sickness even if one's own house doesn't have high CO.
