In America a side effect of our lack of universal care is that every physician has to carry their own malpractice insurance, whereas in most countries you can just get retreated if the first time doesn't work. The Dr might still face consequences is their was actual malpractice but there isn't the shakels of having to do it by the book so strictly.
The creator of the Serotonin hypothesis admitted it was wrong, and he shifted to melatonin's precursor later in his career. The challange with any research in this area is Serotonin and Melatonin both affect biological functions by gradient activity not lock and key receptor models. This pair is how plants and animals respond to seasonal changes which vary year to year. Serotonin is the warm and light lide melatonin is for cool and or dark.
My personal preference is to always suggest getting actual daylight on your retina for 20 min three times a week. Not through glasses, including eyeglasses, but can be through eyelids. That loads transferatin, as in transfer, this loads the enzyme that make serotonin. This then allows the body a better chance to make the intermediate between Serotionin and Melatonin, and is the one believed to help. But the patents have expired so it is like an orphan drug now.
The help aiding sleep is only one function for melatonin. The reason for higher suggested doses is due to its anti-oxident function. From personal experience melatonin needs to be paired with vitamin e to really clear out over night. I take vitamin e as I get into bed right before I take a melatonin sublingual. Another benefit of melatonin is that it upregulates our insulin receptors.
It was a hybrid processor, 16 on the inside 8 bit on the bus. From Wikipedia.
The Motorola 6809 ("sixty-eight-oh-nine") is an 8-bit microprocessor with some 16-bit features. It was designed by Motorola's Terry Ritter and Joel Boney and introduced in 1978. Although source compatible with the earlier Motorola 6800, the 6809 offered significant improvements over it and 8-bit contemporaries like the MOS Technology 6502, including a hardware multiplication instruction, 16-bit arithmetic, system and user stack registers allowing re-entrant code, improved interrupts, position-independent code, and an orthogonal instruction set architecture with a comprehensive set of addressing modes.
Motorola 6809 was a great improvement over Zilog Z80 (previously the best "8-bit" processor), but unfortunately it was introduced too late, in 1979, when the transition towards 16-bit CPUs able to address more than 64 kB of memory had already started.
Motorola had made the mistake of introducing at the same time 2 different incompatible ISAs, one for CPUs covering the low-end of the market, MC6809, and one for CPUs covering the high-end of the market, MC68000. This mistake has cost them the chance of being selected for the IBM PC (because MC68000 was considered too expensive, while MC6809 was not future-proof, with its limited addressing space). After they have seen the success of Intel with its 2 software-compatible CPUs, 8086 for the high end and 8088 for the low end, Motorola has also introduced MC68008, a MC68000 variant for cheaper computers, but it was too late, as the IBM PC became dominant.
> Although source compatible with the earlier Motorola 6800, the 6809 offered significant improvements over it and 8-bit contemporaries like the MOS Technology 6502
For those who don't know the history, the 6502 was initially the 6501, created to be a cut-down, cheaper alternative to the 6800 by many of the same engineers who designed the 6800 at Motorola. Since the idea of copyrighting an instruction set wasn't really a thing yet, the 6501 started out very, very similar to the 6800. Their goal was to basically make a clone of the 6800, except to cut costs so dramatically many changes had to be made, features cut, registers, instructions and interrupts removed. Even so, the 6501 was still pin for pin compatible with the 6800 until Motorola sued Mostek over it. The settlement was that Mostek change the pin out, so the 6501 became the 6502.
Chuck Peddle was the head technical sales person for the 6800 at Motorola and in every customer meeting where he showed early prototypes, customers loved the CPU but said the price was simply a non-starter. He got so sick of hearing it, he quit, joined Mostek, recruited some 6800 engineers and started the 6500 chip project to compete.
Here are the three simultanious things targeted in this experment.
Triple inhibition strategy
Pancreatic cancer remains notoriously difficult to treat, with very poor survival rates and limited effective therapies. The new research aims to combat this by targeting RAF1, EGFR family receptors and STAT3 signalling – nodes that are crucial for tumour growth and survival.
I've lived through this whole epidemic, I remember seeing the origional modern Grafitti guy's work all over North Philly on my way to the doctor in the mid 1970s. That guy's name was CornBread. The artful mural like tagging origionating in the Bronx is another story but there have always been a-holes who tag some scribble over other stuff.
This essay's main point was to wander thr Bazaar and rummage around the wares on their tables. He suggests to find some places to contribute. Not in a brash self serving way but looking to make things and one's self better.
Were you aware that the last time the planet was estimated to have co2 levels over 420ppm the global temperature was 10 degrees Celsius warmer overall? This is the global equilvant of being locked in a car in a sunlit parking lot.
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