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1) Boycott the products and share the idea with others. 2) Show up to town meetings BEFORE these data centers come. 3) Organize! This is the most important. Yes, voting does not matter, but being a loud constituency does.

Boycott what products? I can't boycott my electricity. There is only one provider.

Re #2) I am a tahoe resident and these data centers aren't in my towns. They are far away. I'm not blaming the data centers for these problems, I just disagree with OP that "Tahoe residents kicked the can down the road". Many of us just go to work, take care of our families, and pay our electric bill. Just not sure how this is our fault.


Your power provider is far away from your towns as well. Your officials had agreements for power that were extended multiple times. No one in Tahoe did anything because any of the REAL solutions were "too expensive."

If you want to blame anyone blame yourselves, and the elected officials in charge of Tahoe. You collectively had decades to fix the problem, but you collectively didn't. Now, you have to pay the piper. Sorry but that's the blunt fact.

Don't try to absolve yourself of responsibility when it is your responsibility to know what is going on around you and it's your responsibility to elect officials to make sure they have your best interests at heart. And if they don't and no one steps up, then it's up to you to step up. Otherwise, move, or bear the consequences. You, unfortunately, have to the bear the consequences because nothing when done when there was plenty of time to get something done.


> without invoking the AI bogeyman

If AI is the cause of these data centers, why is it not the bogey man? This sounds like you personally want to use AI with out acknowledging the externalities and the burden your use of AI puts on your fellow citizens.


The idea that capitalism off loads the cost of externalities onto the unwitting public is nothing new. This is just the most recent and obvious version. Air anbd water pollution are the old ones. They make the pollution and the public pays for it with superfund sites or increased health care costs.

The solution is having the consumer pay for the externalities when they use the product. But this would make AI so much more expensive. When you use AI you are exploiting other people. Just keep that in mind.


The last two sentences are drawing downvotes to an otherwise sensible comment.

I agree. But is it a false statement?

It's the tired pattern of absolving the direct bad actors (the corpos themselves), as well as corrupt regulators who give them a pass, in favor of diffusing the responsibility onto individuals. If we're talking about collective action to solve the problem, it should be more of the form of demanding regulation that directly stops the bad actors, rather than this nonsensical fallacy from the same vein as "voting with our wallets".

I think it's people that do that, not capitalism. This happens in every system that has existed in human history.

Absolutely not. The default economic system is anarchy, also known as sharing and mutual aid. You see this even in the reddest of US states, where disaster victims help each other, and a huge pastime is sharing food via potlucks. But all evidence points to anarchical/egalitarian cultures as the baseline mechanism of human organization from prehistory.

Externalities don't exist in anarchic systems, because there is no hierarchical separation between producer and consumer. You can't push off costs to some members of the community when they have equal power to retaliate in kind, and there is no incentive to do so.


> Externalities don't exist in anarchic systems

Sure they do. I do a thing, it benefits me but causes a problem for my neighbor in the process, I say "oh well fuck him", that's a textbook externality.

> they have equal power to retaliate in kind

A convenient fiction often engaged in by proponents of anarchy. In practice if you compare pairs of people at random you will find almost none that can reasonably be described as equal. Equality is something imposed by the law in an attempt to improve our lives on average.

Anarchy lasts exactly as long as it takes people to start banding together and no longer.


Ok so you’d win a community upstream on a river and you build a dam and hive off the water

Downstream 500 miles away another community loses their water source

Those externalities still exist


Haiti is in Anarchy. All sharing and mutual aid is shadowed by resource and power struggle. It is even worse than communism and fascism.

> Haiti is in Anarchy

This is what people say when they have no idea what people mean by the POLITICAL system of Anarchism (Libertarian Socialism).

Anarchism, the political system, is not "chaos". That is propaganda that started during the 1930's. If you want to learn about it, real the Anarchist FAQ.

(I have a degrees in American History and Economics if that matters).

https://theanarchistlibrary.org/library/the-anarchist-faq-ed...


Yeah, and communism has never been given a fair shake, either. For that matter, neither has laissez-faire capitalism.

At some point, you need to accept that your favorite "-ism" has an impedance mismatch with human nature.


Anarchism means "without hierarchy". This how humans organized until the populations of sedentary agricultural communities exploded. I will argue, and keep arguing despite downvotes, that anarchism has the least impedance mismatch with human nature out of every system, because it was the status quo before civilization became the norm.

pretty sure humans had hierarchy from the beginning.

Externalities don't exist in anarchic systems

Neither do computers.


"Scientists have uncovered a striking brain difference linked to psychopathy: people with psychopathic traits were found to have a striatum — a brain region tied to reward, motivation, and decision-making — that was about 10% larger on average than those without such traits. Using MRI scans and psychological assessments on 120 participants, researchers connected this enlarged brain region to thrill-seeking, impulsive behavior, and a stronger drive for stimulation."

Original Paper:

Larger striatal volume is associated with increased adult psychopathy

https://www.sciencedirect.com/science/article/abs/pii/S00223...


It’s not, and if you don’t understand this, you’ve never been around the deaf community before. My college language agreement was filled through sign language. Learning about the deaf community was fascinating.


This is good news, but I still have concerns.

Otoferlin [1] uses calcium as a cofactor. These mutations happen for a reason. The enzyme is not only located in the ear, but also in the brain and bone marrow [2].

Will there be repercussions if the virus leaves the local area when the therapy is injected?

These OTOF mutation have their highest expression in the Turkish population. Many people with other variations of this gene only experience deafness when they have a fever[3]. So in my opinion, I would like to see ten year outcomes before celebrating.

[1] https://www.uniprot.org/uniprotkb/Q9HC10/entry

[2] https://www.proteinatlas.org/ENSG00000115155-OTOF/tissue

[3] https://www.frontiersin.org/journals/cell-and-developmental-...


The Regeneron press release mentions that the therapy includes a hair cell specific regulator for the gene:

https://investor.regeneron.com/news-releases/news-release-de...

That of course doesn't rule out problems, but the treatment doesn't naively turn on the protein production either.


There are a lot of risks with retroviral genetic therapy. However, there are a lot of upsides. I think what we need most, is to gain as much knowledge as possible, to ensure we can treat anything untoward as a result.

In terms of 'leaving the local area', there was a recent treatment intended to be done on one eye first, just in case it did not go as planned. It spread to the other eye:

https://www.cam.ac.uk/research/news/gene-therapy-injection-i...

Viral vector DNA was detected in the anterior segment, retina and optic nerve of the untreated eye. The unexpected visual improvement observed in the untreated eyes could therefore reflect the interocular diffusion of rAAV2/2-ND4. Further investigations are needed to confirm these findings and whether other mechanisms are contributing to this bilateral improvement.

Seeing as the eye was directly injected, it's unclear how it spread. Blood, likely.


Yes, some of the vector was likely cleared from the AH and exposed the contra lateral eye


Patients with fever induced hearing loss regardless of OTOF mutations were specifically excluded (see inclusion criteria on clinical trials.gov for NCT05788536).

With regard to your point about shedding or systemic exposure. If non functional copies of OTOF in the other tissues expressing the gene were to be replaced by functional copies, what is the concern? How would that negatively impact patients? Doesn’t seem like this would/should be a concern.

Also, mutations don’t have to be teleologically beneficial to occur and persist. They can persist because they are not fatal nor do they impair reproductive competence.


Good to have concerns, but if I was deaf I'd weigh them based on how much I want to hear and discuss the risks with my doctor.

Personally I think I would want to hear once in my life, even if it meant a potentially shorter life.

I'm glad the Trump admin prioritized this.


This was not a political decision. These kind of accelerated paths have been available for years for a wide variety of therapies.


> and to Cook that was grow the company.

If you do not see this as teh problem with Tim Cook then I have a gold bar to give you.

https://www.macrumors.com/2025/08/07/tim-cook-gift-to-trump/

I want ethical companies that grow because of good products, not because of market capture and bribes.


And Steve Job's Apple was an ethical company because... he pushed people to produce sleek devices? Which is fine, but then I'd propose that growing the company was ethical because it helped retirement portfolios and employed lots of people. The only Apple product I own is a prime-day deal Beats Pill, but I'm not going to claim that Apple grew because of bribes. People do seem to love their products, in ways I find irrational sometimes.


> And Steve Job's Apple was an ethical company because...

Did I say that?


Yep, Cooks new role is essentially lobbyist.


I'm not going to argue your wants with you because they are your own. Don't buy Apple products if you don't like the way they operate as a company. I don't particularly care for appeasing the administration, either, but it's not like Cook broke the system, so I'm not going to dance on his retirement over it.

Where can I get my gold bar, please?


I like Apple's products. I just purchased an iPhone 17 Pro. It does not mean I cannot still criticize them because of their monopolistic practices.

I was doing Apple support since 1995, I saw how they changed.

I mean, they certainly would never have given Trump a gold bar to forgive this case now, would they?

https://www.cnn.com/2024/03/21/tech/apple-sued-antitrust-doj...


> I want ethical companies

This will never exist.

We should want regulated and lawful companies, which we don't have right now.


> I want ethical companies that grow because of good products, not because of market capture and bribes.

Then avoid becoming a customer/user of companies that grew because of market capture or bribes.


Yes, the reason Apple was so successful at Cook's helm is because he gifted Trump a plaque.


Why do you think they got most of their components exempted from tarrifs?


I'm aware of the open bribery by the administration. That has nothing to do with my comment.


Right, and without that open bribery they would have had 100% tarrifs on all of their iphones, macbooks and semiconductors, which is an overwhelming portion of their revenue.

Now obviously, this only covers a small portion of Tim's reign over apple, but is it not fair to say you'd have a different overall view of his tenure if he was an honest businessman and ate the tarrifs like he was supposed to, probably tanking the stock in the process?


I would probably have a stronger gripe with the ridiculousness of the tariffs than Tim Cook's refusal to bribe the president. Also, to say that not bribing would make him an "honest businessman" is slightly unfair. He has a fiduciary duty to the shareholders, and if he is aware that lobbying to the president personally to avoid tariffs is what it takes to avoid tanking Apple's profit and share price, he is required to do that.


When you realize that everything "we" see is common hallucination, then it will all make sense. The human mind creates the image of a tree, the eye just takes in the light. Change the eye or the mind and our hallucination changes.

So these mushrooms change the mind in a very specific way, but no more strange than putting on red tinted glasses.

Speaking as someone who has involuntary hallucinations, this is a reality taken for granted by most people. I have very different hallucinations when I am dep[ressed vs when I am manic. And you are on the right track in my opinion that "the drug induces the same reaction in a human body, no matter its location."


Grand Unified Theory:

Low intracellular ATP/GTP.

https://www.science.org/doi/10.1126/sciadv.adq6077


Nah, lithium is only treating something that is occurring much deeper: low glucose transport in the brain.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8772148/

This is why APoE e4 alleles are a risk factor, because they control glucose transport.

https://www.nature.com/articles/s41398-025-03550-w

The brain is just losing energy.


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