"I expect they are deidentifying under safe harbor and reselling as much as possible."
You've hit the nail on the head. A key excerpt from Jane.app's privacy policy highlights the potential risks:
"Suppliers and Service Providers. In order to operate our business and provide the Services to our Subscribers and their users, we may need to share a limited amount of personal information, including Patient Data, with our third-party suppliers and service providers." [1]
Currently, I'm attempting to remove my clinical data from Jane.app's servers, but I don't have high hopes for success. Many if not most of these smaller psychology and therapy groups rely on these platforms to store patient data. It is infuriating to me that the moment we disclose the most intimate details of our lives, they become permanent record.
"Removing Data from Jane. Practitioners offering health and medical services are under legal obligation to retain health or medical information that was collected during the course of treatment. It is their responsibility, in collaboration with the Jane Subscriber (clinic owner), to maintain these records, and in many cases, they are simply not allowed, under law, to delete certain records that they created, and they must retain records for a number of years, sometimes 10 years or more." [2]
I disagree with this. For me, the energy is because I have to use less energy doing basic day to day shit. Unmedicated, it takes far more effort and work, and leaves less energy for later tasks.
Imagine doing the dishes. Unmedicated, thats 2 or 3 tasks. Each with a high failure rate, and high cognitive cost.
1. Stop what you’re currently doing.
2. Decide you next task will be to wash the dishes.
3. Wash dishes.
The spoon theory [0] covers this concept well, and can be a useful tool.
> The spoon theory[a] is a metaphor describing the amount of physical and/or mental energy that a person has available for daily activities and tasks, and how it can become limited.
It’s amphetamine. The energy is from the amphetamine. The mechanism of action (norepinephrine and dopamine reputable inhibition) isn’t far from that of cocaine or methamphetamine. Let’s be real here. Amphetamine is known to skew one’s self assessment of their performance while on the drug.
> It’s amphetamine. The energy is from the amphetamine.
Energy still comes from food, and if you forget to eat on stimulants your body will eventually catch up with you.
Like coffee, stimulants let you better tap into that energy.
> The mechanism of action (norepinephrine and dopamine reputable inhibition) isn’t far from that of cocaine or methamphetamine.
Yep, they’re all stimulants. ADHD meds however, are manufactured in very controlled conditions, and taken in specific doses. Street drugs are more variable in quality, ratios, ingredients and strengths, and so not relevant to the treatment of ADHD.
Methamphetamine is a legitimate treatment for the most severe ADHD cases, it’s often a last resort. It’s sold as Desoxyn. It’s rarely used, but it _is used legally and successfully_.
> Let’s be real here. Amphetamine is known to skew one’s self assessment of their performance while on the drug.
If you don’t need it, stimulants are going to have a different effect.
People with ADHD are in my experience, going to be able to self-assess performance on their meds better than off them.
Don’t assume one experience is universal, especially when we’re talking about neurodiversity. Even among those with ADHD, experiences are not universal. We may rhyme, but we don’t always repeat.
The self-assessment is less to do with how efficient I was, and more based on the fact I get things done sooner, because I don't fuck around and get distracted every few minutes. Completing a task significantly sooner/earlier, because I managed to stay on task has a real impact on the energy and time I have to spend on other tasks.
If I only get 80% of the stuff I need to get done before bedtime, there's no chance for me to do other. If I get the stuff I need to get done well before bedtime, there's time left for other things. Skewed self-assessment isn't really a factor in that.
And by the way, the effect on dopamine is secondary. ADHD meds work because they affect glutamate leveles. You all do not have low Dopamine, you have low glutamate.
AADC is an enzyme in the path that converts amino acids into dopamine and PEA/NMPEA (see "biosynthetic pathways" in above link), the latter of which is an endogenous structural isomer of amphetamine.
You're not really making a strong case that this isn't about dopamine or that amphetamine is the wrong thing for it.
Moreover, B6 will make more of these things up until the point that it's no longer the rate limiter in their production, if it ever was. (The rate limiting step for dopamine is ordinarily AAAH converting Tyrosine into L-DOPA). And if you hit a different rate limiter before you have enough dopamine or PEA/NMPEA, what then?
I did not say it is not about dopamine, but it is, at a deeper level, about glutamate. Which is why coffee works so well for ADHD because the stimulant action from caffeine is produced by glutamate.
> Which is why coffee works so well for ADHD because the stimulant action from caffeine is produced by glutamate.
Caffeine also antagonizes adenosine receptors which modulate dopamine. (Caffeine is complicated. Nicotine too.)
> Regardless, here is so much evidence that B6 plays a large role in ADHD and what, you all just ignore it?
The problem is it's the same kind of thing as saying that eating more reduces nutrient deficiencies. It might be more effective than placebo. If you're deficient in one thing and you get more of everything, you get more of that. It might even be the right solution if your underlying problem is actually that you're not eating enough.
But you want the solution that solves the problem as effectively and as narrowly as possible. Unless your underlying problem is actually a B6 deficiency, it's completely plausible that B6 could be more effective than placebo and less effective than Adderall. At which point nobody wants to hear you telling them to give up their Adderall for B6.
There are two groups of accountants / CPA firms; those that work for you and those that work for the government.
The Public can't afford the accountant that works for them.
I've long suspected TurboTax and H&R Block to be in bed with the G. We out not to be surprised if we end up learning Intuit/QuickBooks is secretly sharing their customers financial records, to red flag businesses who tax filings don't match up with their QuickBooks GL.
> "It has been suggested that heat stress induces adaptive hormesis mechanisms similar to exercise, and there are reports of cellular effects induced by whole-body hyperthermia in conjunction with oncology-related interventions"
I wonder if the key is simply raising the temperature of the blood. My understanding is that processes like Regenokine extract your blood, elevate its temperature (which causes it to produce natural anti-inflammatory compounds?) and then inject it back into your body. Perhaps sauna (and exercise?) are doing the same, but to a lesser degree. https://en.wikipedia.org/wiki/Autologous_conditioned_serum
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