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"The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism"

More evidence for Chris Palmer's 'Metabolic Theory of Mental Disorders'





It kinda makes sense if you consider depression to be a mechanism to get into winter hibernation. It's just we can't hibernate and even if we could, somebody has to pay them bills.

That was the funniest social critique I’ve heard in a long time.

But are we built for hibernation? Or is the capacity for depression just a biological mistake for us?

We are not build for anything. It's a legacy codebase. Some stuff stopped working, but nobody removed the surrounding utility codes and the config entry to enable it.

Damned legacy code and technical debt always ruining everything.



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